25) Catalytic Asymmetric Conjugate Reduction. G. Lonardi; R. Parolin; G. Licini; M. Orlandi*. Angew. Chem. Int. Ed. 2023, DOI: 10.1002/anie.202216649


24) Co(Salox)-Catalyzed Enantioselective Reduction of α,β-Unsaturated Esters. G. Pugliese, F. Vaghi; G. Lonardi; G. Licini; M. Orlandi*. Eur. J. Org. Chem. 2023, DOI: 10.1002/ejoc.202201492.

Invited article for the collections #NextGenOrgChem and DCO-SCI Prize and Medal Winners 2020 and 2021.


23) Metal-Free Deoxygenation of Chiral Nitroalkanes: An Easy Entry to α-Substituted Enantiomerically Enriched Nitriles. M. Pirola; C. Faverio; M. Orlandi; M. Benaglia*. Chem. Eur. J. 2021, 27, 10247. 

22) Transition Metal-Catalyzed Enantioselective α-Arylation of Carbonyl Compounds to Give Tertiary Stereocenters. Orlandi,* M. Escudero-Casao, G. Licini, Synthesis, 2021, 53, 4559. 

Invited short review.


21) Cu(I)-Bis(phosphine) Dioxides as catalysts for the Enantioselective α-Arylation of Carbonyl Compounds. M. Escudero-Casao, G. Licini, M. Orlandi,* SynLett, 2021, 32, 1473.

Invited article for the collection Synpacts.


20) Enantioselective α-Arylation of Ketones via a Novel Cu(I)-Bis(phosphine) Dioxide Catalytic System. M. Escudero-Casao, G. Licini, M. Orlandi,* J. Am. Chem. Soc., 2021, 143, 3289.


19) Nucleophilicity Prediction via Multivariate Linear Regression Analysis. M. Orlandi,* M. Escudero-Casao, G. Licini, J. Org. Chem. 2021, 86, 3555.

Microsoft Word - jo0c02952

18) Computational Analysis of Enantioselective Pd-Catalyzed α-Arylation of Ketones. M. Orlandi,* G. Licini, J. Org. Chem. 2020, 85, 11511.


Before UniPd

17 ) Basic principles of substrate activation through non-covalent bond interactions. M. Orlandi,* Phys. Sci. Rev. 2020, DOI: 10.1515/psr-2018-0090. (Invited book chapter)

16) Enantioselective Fluorination of Homoallylic Alcohols Enabled by the Tuning of Non-Covalent Interactions. J. Coelho, A. Matsumoto, M. Orlandi, M. Hilton, M. S. Sigman, F. D. Toste Chem. Sci. 2018, 9, 7153.

15) Enantioselective Synthesis of N,S-Acetals by an Oxidative Pummerer-Type Transformation Using Anionic-Phase Transfer Catalysis. S. Biswas, K. Kubota, M. Orlandi, M. Turberg, D. H. Miles, M. S. Sigman, F. D. Toste Angew. Chem. Int. Ed., 2018, 57, 589.

14) Multidimensional Correlations in Asymmetric Catalysis via Parameterization of Uncatalyzed Transition States. M. Orlandi, F. D. Toste, M. S. Sigman Angew. Chem. Int. Ed., 2017, 56, 14080.

13) Mechanistic Investigations of the Pd(0)-Catalyzed Enantioselec-tive 1,1-Diarylation of Benzyl Acrylates. M. Orlandi, M. J. Hilton, E. Yamamoto, F. D. Toste, M. S. Sigman J. Am. Chem. Soc., 2017, 139, 12688.

12) Parametrization of Non-covalent Interactions for Transition State Interrogation Applied to Asymmetric Catalysis. M. Orlandi, J. A. S. Coelho, M. J. Hilton, F. D. Toste, M. S. Sigman J. Am. Chem. Soc., 2017, 139, 6803.

11) Nickel-Catalyzed Enantioselective Reductive Cross-Coupling of Styrenyl Aziridines. B. P. Woods, M. Orlandi, C.-Y. Huang, M. S. Sigman, A. G. Doyle J. Am. Chem. Soc., 2017, 139, 5688.

10) Development and Analysis of a Pd(0)-Catalyzed Enantioselective 1,1-Diarylation of Acrylates Enabled by Chiral Anion Phase Transfer. E. Yamamoto, M. J. Hilton, M. Orlandi, V. Saini, F. D. Toste, M. S. Sigman J. Am. Chem. Soc., 2016, 138, 15877.

9) Recent developments in the reduction of aromatic and aliphatic nitro compounds to amines. M. Orlandi, D. Brenna, R. Harms, S. Jost, M. Benaglia Org. Process Res. Dev., 2018, 22, 430.

8) Kinetics versus thermodynamics in the proline catalyzed aldol reaction. M. Orlandi, M. Ceotto, M. Benaglia Chem. Sci. 2016, 7, 5421.

7) HSiCl3‑Mediated Reduction of Nitro-Derivatives to Amines: Is Tertiary Amine-Stabilized SiCl2 the Actual Reducing Species? M. Orlandi, M. Benaglia, F. Tosi, R. Annunziata, F. Cozzi J. Org. Chem. 2016, 81, 3037.

6) Metal-Free Reduction of Aromatic and Aliphatic Nitro Compounds to Amines: A HSiCl3-Mediated Reaction of Wide General Applicability. M. Orlandi, F. Tosi, M. Bonsignore, M. Benaglia, Org. Lett. 2015, 17, 3941.

5) Three Dimensional (3D) Printing: A Straightforward, User-Friendly Protocol To Convert Virtual Chemical Models to Real-Life Objects. S. Rossi, M. Benaglia, D. Brenna, R. Porta, M. Orlandi J. Chem. Educ. 2015, 92, 1398.

4) Enantioselective Organocatalytic Reduction of β-Trifluoromethyl Nitroalkenes: An Efficient Strategy for the Synthesis of Chiral β-Trifluoromethyl Amines. E. Massolo, M. Benaglia, M. Orlandi, S. Rossi, G. Celentano, Chem. Eur. J. 2015, 21, 3589.

3) Synthesis, Characterization and Organocatalytic Activity of Chiral Tetrathiahelicene Diphosphine Oxides. S. Cauteruccio, D. Dova, M. Benaglia, A. Genoni, M. Orlandi, E. Licandro, Eur. J. Org. Chem. 2014, 2694.

2) Enantioselective reduction of ketoimines promoted by easily available (S)-proline derivatives. M. Bonsignore, M. Benaglia, L. Raimondi, M. Orlandi, G. Celentano, Beilstein J. Org. Chem. 2013, 9, 633.

1) 2-aminoimidazolyl and 2-aminopyridyl (S)-prolinamides as versatile multifunctional organic catalysts for aldol, Michael, and Diels–Alder reactions. M. Orlandi, M. Benaglia, L. Raimondi, G. Celentano, Eur. J. Org. Chem. 2013, 2346.